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张政副教授

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张政副教授

药理学系

电话:0731-82355077

传真:0731-82355078

电子邮箱:zzhang@csu.edu.cn, zzhang510@gmail.com

 

学习工作经历

1998/09 2003/07,武汉大学,临床医学本科

2003/09 2008/07,中山大学,心血管药理学硕博连读

2008/09 2009/12University of Connecticut Health Center,离子通道药理学博士后

2010/01 2013/01The Queen’s Medical Center,离子通道药理学博士后

2013/02 至今,中南大学药学院药理学系

 

研究领域

离子通道药理学;离子通道生物物理学;钙离子信号转导

 

 

发表论文

1.      Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, Penner R. N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation. Oncotarget. 2014; 5(17):7625-34.

2.      Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A. The TRPM6 kinase domain determines the MgATP-sensitivity of TRPM7/M6 heteromeric ion channels. J Biol Chem. 2014; 289(8):5217-27

3.      Yu H*, Zhang Z*, Lis A, Penner R, Fleig A. TRPM7 is regulated by halides through its kinase domain. Cell Mol Life Sci. 2013; 70(15):2757-71

4.      Yu YH, Zhang L, Wu DS, Zhang Z, Huang FF, Zhang J, Chen XP, Liang DS, Zeng H, Chen FP. MiR-223 Regulates human embryonic stem cell differentiation by targeting the IGF-1R/Akt signaling pathway. PLoS One. 2013;8(11):e78769

5.      Zhang Z#, Wang M, Fan XH, Chen JH, Guan YY, Tang YB#. Upregulation of trpm7 channels by angiotensin ii triggers phenotypic switching of vascular smooth muscle cells of ascending aorta. Circ Res. 2012;111(9):1137-46

6.      Wang M*, Yang H*, Zheng LY*, Zhang Z*, Tang YB, Wang GL, Du YH, Lv XF, Liu J, Zhou JG, Guan YY. Downregulation of tmem16a calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation. Circulation. 2012;125:697-707

7.      Zhang Z, Wang M, Xue SJ, Liu DH, Tang YB. Simvastatin ameliorates angiotensin ii-induced endothelial dysfunction through restoration of rho-bh4-enos-no pathway. Cardiovasc Drugs Ther. 2012;26:31-40

8.      Shi XL*, Wang GL*, Zhang Z*, Liu YJ, Chen JH, Zhou JG, Qiu QY, Guan YY. Alteration of volume-regulated chloride movement in rat cerebrovascular smooth muscle cells during hypertension. Hypertension. 2007;49:1371-1377

9.      Huang EW, Xue SJ, Zhang Z, Zhou JG, Guan YY, Tang YB. Vinpocetine inhibits breast cancer cells growth in vitro and in vivo. Apoptosis. 2012;17(10):1120-30

10.  Zierler S, Yao G, Zhang Z, Kuo WC, Porzgen P, Penner R, Horgen FD, Fleig A. Waixenicin a inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (trpm7) channels. J Biol Chem. 2011;286:39328-39335

11.  Du J, Xie J, Zhang Z, Tsujikawa H, Fusco D, Silverman D, Liang B, Yue L. Trpm7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res. 2010;106:992-1003

12.  Chen HC, Xie J, Zhang Z, Su LT, Yue L, Runnels LW. Blockade of trpm7 channel activity and cell death by inhibitors of 5-lipoxygenase. PLoS One. 2010;5:e11161

13.  Zeng H, Guo M, Martins-Taylor K, Wang X, Zhang Z, Park JW, Zhan S, Kronenberg MS, Lichtler A, Liu HX, Chen FP, Yue L, Li XJ, Xu RH. Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One. 2010;5:e11853

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